Anti-CAPN1 antibody (20-330) (STJ11104473)

Name: Anti-CAPN1 antibody (20-330) (STJ11104473)
SKU: STJ11104473
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104473

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Short Description	Rabbit polyclonal Calpain-1 Catalytic Subunit (20-330) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	CAPN1
Gene ID	823
Uniprot ID	CAN1_HUMAN
Immunogen Region	20-330
Immunogen Sequence	KQRARELGLGRHENAIKYLG QDYEQLRVRCLQSGTLFRDE AFPPVPQSLGYKDLGPNSSK TYGIKWKRPTELLSNPQFIV DGATRTDICQGALGDCWLLA AIASLTLNDTLLHRVVPHGQ SFQNGYAGIFHFQLWQFGEW VDVVVDDLLPIKDGKLVFVH SAEGNEFWSALLEKAYAKVN GSYEALSGGSTSEGFEDFTG GVTEWYELRKAPSDLYQIIL KALERGSLLGCSIDISSVL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 20-330 of human Calpain 1 (NP_005177.2).

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Function	Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7).
Protein Name	Calpain-1 Catalytic Subunit Calcium-Activated Neutral Proteinase 1 Canp 1 Calpain Mu-Type Calpain-1 Large Subunit Cell Proliferation-Inducing Gene 30 Protein Micromolar-Calpain Mucanp
Database Links	Reactome: R-HSA-1474228 Reactome: R-HSA-6798695 Reactome: R-HSA-6809371 Reactome: R-HSA-8862803
Cellular Localisation	Cytoplasm Cell Membrane Translocates To The Plasma Membrane Upon Ca(2+) Binding In Granular Keratinocytes And In Lower Corneocytes Colocalizes With Flg And Flg2
Alternative Antibody Names	Anti-Calpain-1 Catalytic Subunit antibody Anti-Calcium-Activated Neutral Proteinase 1 antibody Anti-Canp 1 antibody Anti-Calpain Mu-Type antibody Anti-Calpain-1 Large Subunit antibody Anti-Cell Proliferation-Inducing Gene 30 Protein antibody Anti-Micromolar-Calpain antibody Anti-Mucanp antibody Anti-CAPN1 antibody Anti-CANPL1 antibody Anti-PIG30 antibody

Information sourced from Uniprot.org