Anti-CANX antibody (EERPWLWVVYILTVAL) [3H4A7] (STJ97891)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2b
ImmunogenSynthetic peptide corresponding to aa (CEthe amino acidEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.
General Information
| Short Description | Mouse monoclonal anti-Calnexin (EERPWLWVVYILTVAL) for use in WB, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 3H4A7 |
| Isotype | IgG2b |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CANX |
| Gene ID | 821 |
| Uniprot ID | CALX_HUMAN |
| Immunogen | Synthetic peptide corresponding to aa (CEthe amino acidEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH. |
| Immunogen Region | EERPWLWVVYILTVAL |
| Specificity | Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein. |
Additional Info
| Function | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Protein Name | CalnexinIp90Major Histocompatibility Complex Class I Antigen-Binding Protein P88P90 |
| Database Links | Reactome: R-HSA-168316Reactome: R-HSA-2132295Reactome: R-HSA-8984722Reactome: R-HSA-901042Reactome: R-HSA-9020956Reactome: R-HSA-9683686Reactome: R-HSA-9694548Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinMitochondrion MembraneMelanosome MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvThe Palmitoylated Form Preferentially Localizes To The Perinuclear Rough ErLocalizes To Endoplasmic Reticulum Mitochondria-Associated Membrane (Mams) That Connect The Endoplasmic Reticulum And The Mitochondria |
| Alternative Antibody Names | Anti-Calnexin antibodyAnti-Ip90 antibodyAnti-Major Histocompatibility Complex Class I Antigen-Binding Protein P88 antibodyAnti-P90 antibodyAnti-CANX antibody |
Information sourced from Uniprot.org