Anti-CANX antibody (550 aa C-Term) {DyLight®488} (STJ140256)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationDyLight®488
IsotypeIgG
ImmunogenPurified recombinant peptide within residues 550 aa to the C-terminus of human CANX produced in E. coli.
General Information
| Short Description | Goat polyclonal CANX (550 aa C-Term) antibody for use in WB, IF and IHC-F in human, rat, mouse, canine and monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/IHC-F |
| Host | Goat |
| Reactivity | Human/Rat/Mouse/Canine/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | DyLight®488 |
| Concentration | 2 mg/mL |
| Purification | Epitope affinity purified |
| Dilution Range | WB 1:500-1:5000IF 1:50-1:500IHC-F 1:200-1:1000 |
| Formulation | PBS, 20% Glycerol, 0.05% ProClin® and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | CANX |
| Gene ID | 821 |
| Uniprot ID | CALX_HUMAN |
| Immunogen | Purified recombinant peptide within residues 550 aa to the C-terminus of human CANX produced in E. coli. |
| Immunogen Region | 550 aa C-Term |
| Immunogen Sequence | KSDAEEDGGTVSQEEEDRKP SDAEEDGGTVSQEEEDRKPK |
| Specificity | Detects a band of 90 kDa by Western blot whole cell lysates. |
Additional Info
| Function | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Protein Name | CalnexinIp90Major Histocompatibility Complex Class I Antigen-Binding Protein P88P90 |
| Database Links | Reactome: R-HSA-168316Reactome: R-HSA-2132295Reactome: R-HSA-8984722Reactome: R-HSA-901042Reactome: R-HSA-9020956Reactome: R-HSA-9683686Reactome: R-HSA-9694548Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinMitochondrion MembraneMelanosome MembraneIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvThe Palmitoylated Form Preferentially Localizes To The Perinuclear Rough ErLocalizes To Endoplasmic Reticulum Mitochondria-Associated Membrane (Mams) That Connect The Endoplasmic Reticulum And The Mitochondria |
| Alternative Antibody Names | Anti-Calnexin antibodyAnti-Ip90 antibodyAnti-Major Histocompatibility Complex Class I Antigen-Binding Protein P88 antibodyAnti-P90 antibodyAnti-CANX antibody |
Information sourced from Uniprot.org