Anti-CAMKK1 antibody (STJA0010268)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human CAMKK1/2
General Information
| Short Description | Rabbit polyclonal anti-Calcium/calmodulin-dependent protein kinase kinase 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CAMKK1 |
| Gene ID | 84254 |
| Uniprot ID | KKCC1_HUMAN |
| Immunogen | Synthesized peptide derived from human CAMKK1/2 |
| Specificity | This antibody detects endogenous levels of CAMKK1/2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Appears to be autophosphorylated in a Ca(2+)/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca(2+)/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4. |
| Function | Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Kinase 1Cam-Kk 1Cam-Kinase Kinase 1Camkk 1Cam-Kinase Iv KinaseCalcium/Calmodulin-Dependent Protein Kinase Kinase AlphaCam-Kk AlphaCam-Kinase Kinase AlphaCamkk Alpha |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-442729Reactome: R-HSA-9619229 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Kinase 1 antibodyAnti-Cam-Kk 1 antibodyAnti-Cam-Kinase Kinase 1 antibodyAnti-Camkk 1 antibodyAnti-Cam-Kinase Iv Kinase antibodyAnti-Calcium/Calmodulin-Dependent Protein Kinase Kinase Alpha antibodyAnti-Cam-Kk Alpha antibodyAnti-Cam-Kinase Kinase Alpha antibodyAnti-Camkk Alpha antibodyAnti-CAMKK1 antibodyAnti-CAMKKA antibody |
Information sourced from Uniprot.org