| Host: |
Mouse |
| Applications: |
FC/IP |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-CD10/CALLA is suitable for use in Flow Cytometry and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
MEM-78 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Concentration: |
1 mg/mL |
| Dilution Range: |
FC 1 µg/ml-IP |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
MME |
| Gene ID: |
4311 |
| Uniprot ID: |
NEP_HUMAN |
| Immunogen: |
NALM-6 human pre-B cell line |
| Post Translational Modifications | Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. |
| Function | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. |
| Protein Name | NeprilysinAtriopeptidaseCommon Acute Lymphocytic Leukemia AntigenCallaEnkephalinaseNeutral Endopeptidase 24.11NepNeutral EndopeptidaseSkin Fibroblast ElastaseSfeCd Antigen Cd10 |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-5578768Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Neprilysin antibodyAnti-Atriopeptidase antibodyAnti-Common Acute Lymphocytic Leukemia Antigen antibodyAnti-Calla antibodyAnti-Enkephalinase antibodyAnti-Neutral Endopeptidase 24.11 antibodyAnti-Nep antibodyAnti-Neutral Endopeptidase antibodyAnti-Skin Fibroblast Elastase antibodyAnti-Sfe antibodyAnti-Cd Antigen Cd10 antibodyAnti-MME antibodyAnti-EPN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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