Anti-CALCRL antibody [SAA0150] (STJA0027398)
SPECIFICATIONS
ClonalityMonoclonal
HostHuman
ConjugationUnconjugated
IsotypeIgG2L
General Information
| Short Description | Human monoclonal Calcitonin Gene-Related Peptide Type 1 Receptor antibody for use in FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC |
| Host | Human |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0150 |
| Isotype | IgG2L |
| Conjugation | Unconjugated |
| Concentration | 1.12 mg/ml |
| Purification | Protein A/G purified from cell culture supernatant. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | CALCRL |
| Gene ID | 10203 |
| Uniprot ID | CALRL_HUMAN |
Additional Info
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. |
| Protein Name | Calcitonin Gene-Related Peptide Type 1 ReceptorCgrp Type 1 ReceptorCalcitonin Receptor-Like ReceptorCrlr |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcitonin Gene-Related Peptide Type 1 Receptor antibodyAnti-Cgrp Type 1 Receptor antibodyAnti-Calcitonin Receptor-Like Receptor antibodyAnti-Crlr antibodyAnti-CALCRL antibodyAnti-CGRPR antibody |
Information sourced from Uniprot.org