Anti-CALCRL antibody (430-461) (STJ111275)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CALCRL (430-461) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CALCRL |
| Gene ID | 10203 |
| Uniprot ID | CALRL_HUMAN |
| Immunogen Region | 430-461 |
| Immunogen Sequence | GIEFVLIPWRPEGKIAEEVY DYIMHILMHFQGLLVSTIFC FFNGEVQAILRRNWNQYKIQ FGNSFSNSEALRSASYTVST ISDGPGYSHDCPSEHLNGKS IHDIENVLLKPENLYN |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 346-445 of human CALCRL (NP_005786.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in the lung and heart. |
| Function | G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. |
| Protein Name | Calcitonin Gene-Related Peptide Type 1 ReceptorCgrp Type 1 ReceptorCalcitonin Receptor-Like ReceptorCrlr |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-9856530 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcitonin Gene-Related Peptide Type 1 Receptor antibodyAnti-Cgrp Type 1 Receptor antibodyAnti-Calcitonin Receptor-Like Receptor antibodyAnti-Crlr antibodyAnti-CALCRL antibodyAnti-CGRPR antibody |
Information sourced from Uniprot.org