• STJ72328 (1µg/ml) staining of Human Colorectal cancer lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CADM1 antibody (Internal) (STJ72328)

SKU:
STJ72328-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CADM1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CADM1
Gene ID: 23705
Uniprot ID: CADM1_HUMAN
Immunogen Region: Internal
Accession Number: NP_055148.3; NP_001091987.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_055148.3; NP_001091987.1).
Immunogen Sequence: NLQTQRYLEVQ
Function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node. Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells. Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. May contribute to the less invasive phenotypes of lepidic growth tumor cells.
Protein Name Cell Adhesion Molecule 1
Immunoglobulin Superfamily Member 4
Igsf4
Nectin-Like Protein 2
Necl-2
Spermatogenic Immunoglobulin Superfamily
Sgigsf
Synaptic Cell Adhesion Molecule
Syncam
Tumor Suppressor In Lung Cancer 1
Tslc-1
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-420597
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Synapse
Localized To The Basolateral Plasma Membrane Of Epithelial Cells In Gall Bladder
Alternative Antibody Names Anti-Cell Adhesion Molecule 1 antibody
Anti-Immunoglobulin Superfamily Member 4 antibody
Anti-Igsf4 antibody
Anti-Nectin-Like Protein 2 antibody
Anti-Necl-2 antibody
Anti-Spermatogenic Immunoglobulin Superfamily antibody
Anti-Sgigsf antibody
Anti-Synaptic Cell Adhesion Molecule antibody
Anti-Syncam antibody
Anti-Tumor Suppressor In Lung Cancer 1 antibody
Anti-Tslc-1 antibody
Anti-CADM1 antibody
Anti-IGSF4 antibody
Anti-IGSF4A antibody
Anti-NECL2 antibody
Anti-SYNCAM antibody
Anti-TSLC1 antibody

Information sourced from Uniprot.org

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