| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNG8 (Internal Region) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
CACNG8 |
| Gene ID: |
59283 |
| Uniprot ID: |
CCG8_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Specific for CACNG8. |
| Immunogen: |
A synthetic peptide from the internal region of human CACNG8 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in mouse and rat. |
| Post Translational Modifications | Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. |
| Function | Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. |
| Protein Name | Voltage-Dependent Calcium Channel Gamma-8 SubunitNeuronal Voltage-Gated Calcium Channel Gamma-8 SubunitTransmembrane Ampar Regulatory Protein Gamma-8Tarp Gamma-8 |
| Database Links | Reactome: R-HSA-399719Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-5682910 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Density Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Gamma-8 Subunit antibodyAnti-Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit antibodyAnti-Transmembrane Ampar Regulatory Protein Gamma-8 antibodyAnti-Tarp Gamma-8 antibodyAnti-CACNG8 antibodyAnti-CACNG6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
