Anti-CACNB2 antibody (C-Term) (STJ13100828)

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STJ13100828-100
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Short Description :Rabbit polyclonal anti-CACNB2 (C-Term) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC/WB
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:IgG purified
Dilution Range:IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Formulation:Lyophilised
Storage Instruction:Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol:CACNB2
Gene ID:783
Uniprot ID:CACB2_HUMAN
Immunogen:A synthetic peptide from the c-terminal region of human CACNB2 (CAB2, MYSB) conjugated to an immunogenic carrier protein was used as the immunogen.
Immunogen Region:C-Term
Specificity:Specific for CACNB2.
Post Translational Modifications Regulated through phosphorylation at Thr-554 by CaMK2D.
Function Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current. Plays a role in shifting voltage dependencies of activation and inactivation of the channel. May modulate G protein inhibition. May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. Involved in membrane targeting of the alpha-1 subunit CACNA1C.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Beta-2
Cab2
Calcium Channel Voltage-Dependent Subunit Beta 2
Lambert-Eaton Myasthenic Syndrome Antigen B
Mysb
Database Links Reactome: R-HSA-112308
Reactome: R-HSA-400042
Reactome: R-HSA-419037
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Reactome: R-HSA-9662360
Reactome: R-HSA-9856532
Cellular Localisation Cell Membrane
Sarcolemma
Peripheral Membrane Protein
Cytoplasmic Side
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Beta-2 antibody
Anti-Cab2 antibody
Anti-Calcium Channel Voltage-Dependent Subunit Beta 2 antibody
Anti-Lambert-Eaton Myasthenic Syndrome Antigen B antibody
Anti-Mysb antibody
Anti-CACNB2 antibody
Anti-CACNLB2 antibody
Anti-MYSB antibody

Information sourced from Uniprot.org