Anti-CACNA2D3 antibody (STJ13100087)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from rat CACNA2D3 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in mouse.
General Information
| Short Description | Rabbit polyclonal anti-CACNA2D3 for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Cacna2d3 |
| Gene ID | 12294 |
| Uniprot ID | CA2D3_MOUSE |
| Immunogen | A synthetic peptide from rat CACNA2D3 conjugated to blue carrier protein was used as the antigen. The antigen is homologous in mouse. |
| Specificity | Specific for CACNA2D3. |
Additional Info
| Post Translational Modifications | N-glycosylated. May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 |
| Database Links | Reactome: R-MMU-112308 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-3 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-3 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-3 - Voltage-Dependent Calcium Channel Subunit Delta-3 antibodyAnti-Cacna2d3 antibody |
Information sourced from Uniprot.org