| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-dependent calcium channel subunit alpha-2/delta-2 (540-620 aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA2D2 |
| Gene ID: |
9254 |
| Uniprot ID: |
CA2D2_HUMAN |
| Immunogen Region: |
540-620 aa |
| Specificity: |
The antibody detects endogenous CaV Alpha 2 Delta 2 protein |
| Immunogen: |
Synthetic peptide derived from CaV Alpha 2 Delta 2 at the amino acid range 540-620 |
| Post Translational Modifications | May be proteolytically processed into subunits alpha-2-2 and delta-2 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role. |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. |
| Protein Name | Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-400042Reactome: R-HSA-422356Reactome: R-HSA-5576892Reactome: R-HSA-5576893Reactome: R-HSA-9662360 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinColocalizes With Cacna1a In Lipid Raft Fractions |
| Alternative Antibody Names | Anti-Voltage-Dependent Calcium Channel Subunit Alpha-2/Delta-2 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha-2/Delta-2 Cleaved Into - Voltage-Dependent Calcium Channel Subunit Alpha-2-2 - Voltage-Dependent Calcium Channel Subunit Delta-2 antibodyAnti-CACNA2D2 antibodyAnti-KIAA0558 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
