| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-dependent T-type calcium channel subunit alpha-1I3.3 (210-290 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1I |
| Gene ID: |
8911 |
| Uniprot ID: |
CAC1I_HUMAN |
| Immunogen Region: |
210-290 aa |
| Specificity: |
Cav3.3 protein (A209) detects endogenous levels of Cav3.3 |
| Immunogen: |
Synthetic peptide derived from Cav3.3 at the amino acid range 210-290 |
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1iVoltage-Gated Calcium Channel Subunit Alpha Cav3.3Ca(V3.3 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1i antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.3 antibodyAnti-Ca(V3.3 antibodyAnti-CACNA1I antibodyAnti-KIAA1120 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
