Anti-CACNA1G antibody (Internal) (STJ72033)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-CACNA1G (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Rat/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments in Human Brain lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | CACNA1G |
| Gene ID | 8913 |
| Uniprot ID | CAC1G_HUMAN |
| Accession Number | NP_061496.2, NP_938192.1, NP_938194.1, NP_938198.1, NP_938199.1, NP_938200.1, NP_938407.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | AEEISKREDASGQLS |
| Specificity | This antibody is expected to recognize isoform 1 (NP_061496.2) , 4 (NP_938199.1) , 5 (NP_938194.1) , 8 (NP_938198.1) , 9 (NP_938192.1) , 10 (NP_938200.1) and isoform 15 (NP_938407.1). |
Additional Info
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Isoform 2: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1gCav3.1cNbr13Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1g antibodyAnti-Cav3.1c antibodyAnti-Nbr13 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 antibodyAnti-CACNA1G antibodyAnti-KIAA1123 antibody |
Information sourced from Uniprot.org