| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Voltage-dependent T-type calcium channel subunit alpha-1G (360-440 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-300IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1G |
| Gene ID: |
8913 |
| Uniprot ID: |
CAC1G_HUMAN |
| Immunogen Region: |
360-440 aa |
| Specificity: |
CAC1G Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 360-440 |
| Post Translational Modifications | In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. |
| Protein Name | Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1gCav3.1cNbr13Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-445355 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasm |
| Alternative Antibody Names | Anti-Voltage-Dependent T-Type Calcium Channel Subunit Alpha-1g antibodyAnti-Cav3.1c antibodyAnti-Nbr13 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav3.1 antibodyAnti-CACNA1G antibodyAnti-KIAA1123 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
