• Western blot analysis of lysates from Rat kidney, using CACNA1D Rabbit polyclonal antibody (STJ11102779) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-CACNA1D antibody (1882-2181) (STJ11102779)

SKU:
STJ11102779

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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CACNA1D (1882-2181) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CACNA1D
Gene ID: 776
Uniprot ID: CAC1D_HUMAN
Immunogen Region: 1882-2181
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1882-2181 of human CACNA1D (NP_000711.1).
Immunogen Sequence: RQNYGYYSRYPGRNIDSERP RGYHHPQGFLEDDDSPVCYD SRRSPRRRLLPPTPASHRRS SFNFECLRRQSSQEEVPSSP IFPHRTALPLHLMQQQIMAV AGLDSSKAQKYSPSHSTRSW ATPPATPPYRDWTPCYTPLI QVEQSEALDQVNGSLPSLHR SSWYTDEPDISYRTFTPASL TVPSSFRNKNSDKQRSADSL VEAVLISEGLGRYARDPKFV SATKHEIADACDLTIDEME
Tissue Specificity Expressed in pancreatic islets and in brain, where it has been seen in cerebral cortex, hippocampus, basal ganglia, habenula and thalamus. Expressed in the small cell lung carcinoma cell line SCC-9. No expression in skeletal muscle.
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2
Voltage-Gated Calcium Channel Subunit Alpha Cav1.3
Database Links Reactome: R-HSA-400042
Reactome: R-HSA-419037
Reactome: R-HSA-422356
Reactome: R-HSA-9662360
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1d antibody
Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 2 antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.3 antibody
Anti-CACNA1D antibody
Anti-CACH3 antibody
Anti-CACN4 antibody
Anti-CACNL1A2 antibody
Anti-CCHL1A2 antibody

Information sourced from Uniprot.org

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