• STJ71676 (1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CACNA1C antibody (C-Term) (STJ71676)

SKU:
STJ71676-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CACNA1C (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1.0-3.0µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CACNA1C
Gene ID: 775
Uniprot ID: CAC1C_HUMAN
Immunogen Region: C-Term
Accession Number: NP_000710.5; NP_955630.2; NP_001161097.1; NP_001123299.1; NP_001123301.1; NP_001161096.1; NP_001123302.1; NP_001123303.1 and more
Specificity: This antibody is expected to recognise all reported human isoforms.
Immunogen Sequence: RARGRPSEEELQD
Post Translational Modifications Phosphorylation by PKA at Ser-1981 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA.
Function Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues.
Protein Name Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c
Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle
Voltage-Gated Calcium Channel Subunit Alpha Cav1.2
Database Links Reactome: R-HSA-400042
Reactome: R-HSA-419037
Reactome: R-HSA-422356
Reactome: R-HSA-5576892
Reactome: R-HSA-5576893
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Sarcolemma
Perikaryon
Postsynaptic Density Membrane
Cell Projection
Dendrite
T-Tubule
Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane
Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact
The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane
Alternative Antibody Names Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibody
Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibody
Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibody
Anti-CACNA1C antibody
Anti-CACH2 antibody
Anti-CACN2 antibody
Anti-CACNL1A1 antibody
Anti-CCHL1A1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance