| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CACNA1B (C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CACNA1B |
| Gene ID: |
774 |
| Uniprot ID: |
CAC1B_HUMAN |
| Immunogen Region: |
C-Term |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 2200 to the C-terminus of human CACNA1B (NP_000709.1). |
| Immunogen Sequence: |
SITYKTANSSPIHFAGAQTS LPAFSPGRLSRGLSEHNALL QRDPLSQPLAPGSRIGSDPY LGQRLDSEASVHALPEDTLT FEEAVATNSGRSSRTSYVSS LTSQSHPLRRVPNGYHCTLG LSSGGRARHSYHHPDQDHWC |
| Tissue Specificity | Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum. |
| Post Translational Modifications | Phosphorylated in vitro by CaM-kinase II, PKA, PKC and CGPK. |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals. |
| Protein Name | Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1bBrain Calcium Channel IiiBiiiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 5Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 |
| Database Links | Reactome: R-HSA-112308 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent N-Type Calcium Channel Subunit Alpha-1b antibodyAnti-Brain Calcium Channel Iii antibodyAnti-Biii antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 5 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.2 antibodyAnti-CACNA1B antibodyAnti-CACH5 antibodyAnti-CACNL1A5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
