Anti-CACNA1A antibody (1000-1050 aa) (STJ13100814)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen. The antigen shares 87% identity with mouse and rat sequence.
General Information
| Short Description | Rabbit polyclonal anti-CACNA1A (1000-1050 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CACNA1A |
| Gene ID | 773 |
| Uniprot ID | CAC1A_HUMAN |
| Immunogen | A synthetic peptide from aa region 1000-1050 of human CACNA1A conjugated to blue carrier protein was used as the antigen. The antigen shares 87% identity with mouse and rat sequence. |
| Immunogen Region | 1000-1050 aa |
| Specificity | Specific for CACNA1A. |
Additional Info
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282). They are however insensitive to dihydropyridines (DHP). |
| Protein Name | Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1aBrain Calcium Channel IBiCalcium Channel - L Type - Alpha-1 Polypeptide Isoform 4Voltage-Gated Calcium Channel Subunit Alpha Cav2.1 |
| Database Links | Reactome: R-HSA-112308Reactome: R-HSA-422356 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Voltage-Dependent P/Q-Type Calcium Channel Subunit Alpha-1a antibodyAnti-Brain Calcium Channel I antibodyAnti-Bi antibodyAnti-Calcium Channel - L Type - Alpha-1 Polypeptide Isoform 4 antibodyAnti-Voltage-Gated Calcium Channel Subunit Alpha Cav2.1 antibodyAnti-CACNA1A antibodyAnti-CACH4 antibodyAnti-CACN3 antibodyAnti-CACNL1A4 antibody |
Information sourced from Uniprot.org