| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Calcium-binding protein 1 is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CABP1 |
| Gene ID: |
9478 |
| Uniprot ID: |
CABP1_HUMAN |
| Specificity: |
The antibody detects endogenous CABP protein |
| Immunogen: |
Synthetic Peptide of CABP |
| Post Translational Modifications | Phosphorylated. The phosphorylation regulates the activity. |
| Function | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. |
| Protein Name | Calcium-Binding Protein 1Cabp1CalbrainCaldendrin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembraneLipid-AnchorCytoplasmic SideGolgi ApparatusPostsynaptic DensityL-Cabp1 Is Associated Most Likely With The Cytoskeletal StructuresWhereas S-Cabp1 Is Localized At Or Near The Plasma MembraneIsoform L-Cabp1: CytoplasmIsoform S-Cabp1: CytoplasmCell CortexS-Cabp1 Is Localized At Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcium-Binding Protein 1 antibodyAnti-Cabp1 antibodyAnti-Calbrain antibodyAnti-Caldendrin antibodyAnti-CABP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
