• Immunohistochemistry analysis of CABP1 in paraffin-embedded Mouse kidney using CABP1 Rabbit polyclonal antibody (STJ11100360) at dilution of 1:50 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of CABP1 in paraffin-embedded Human colon using CABP1 Rabbit polyclonal antibody (STJ11100360) at dilution of 1:50 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using CABP1 Rabbit polyclonal antibody (STJ11100360) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-CABP1 antibody (1-100) (STJ11100360)

SKU:
STJ11100360

£112.50 - £522.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CABP1 (1-100) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CABP1
Gene ID: 9478
Uniprot ID: CABP1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CABP1 (NP_001028849.1).
Immunogen Sequence: MGGGDGAAFKRPGDGARLQR VLGLGSRREPRSLPAGGPAP RRTAPPPPGHASAGPAAMSS HIAKSESKTSLLKAAAAAAS GGSRAPRHGPARDPGLPSRR
Tissue Specificity Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum.
Post Translational Modifications Phosphorylated. The phosphorylation regulates the activity.
Function Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina.
Protein Name Calcium-Binding Protein 1
Cabp1
Calbrain
Caldendrin
Database Links Reactome: R-HSA-9662360
Cellular Localisation Cytoplasm
Cytoskeleton
Perinuclear Region
Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Golgi Apparatus
Postsynaptic Density
L-Cabp1 Is Associated Most Likely With The Cytoskeletal Structures
Whereas S-Cabp1 Is Localized At Or Near The Plasma Membrane
Isoform L-Cabp1: Cytoplasm
Isoform S-Cabp1: Cytoplasm
Cell Cortex
S-Cabp1 Is Localized At Or Near The Plasma Membrane
Alternative Antibody Names Anti-Calcium-Binding Protein 1 antibody
Anti-Cabp1 antibody
Anti-Calbrain antibody
Anti-Caldendrin antibody
Anti-CABP1 antibody

Information sourced from Uniprot.org

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