| Tissue Specificity | Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum. |
| Post Translational Modifications | Phosphorylated. The phosphorylation regulates the activity. |
| Function | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. |
| Protein Name | Calcium-Binding Protein 1Cabp1CalbrainCaldendrin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembraneLipid-AnchorCytoplasmic SideGolgi ApparatusPostsynaptic DensityL-Cabp1 Is Associated Most Likely With The Cytoskeletal StructuresWhereas S-Cabp1 Is Localized At Or Near The Plasma MembraneIsoform L-Cabp1: CytoplasmIsoform S-Cabp1: CytoplasmCell CortexS-Cabp1 Is Localized At Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcium-Binding Protein 1 antibodyAnti-Cabp1 antibodyAnti-Calbrain antibodyAnti-Caldendrin antibodyAnti-CABP1 antibody |
Information sourced from Uniprot.org
