| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CABP1 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-Recommended for use at 0.5-2µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CABP1 |
| Gene ID: |
9478 |
| Uniprot ID: |
CABP1_HUMAN |
| Immunogen Region: |
N-Term |
| Accession Number: |
NP_112482.1; NP_004267.2 |
| Specificity: |
This antibody is expected to recognise both Human isoforms. |
| Immunogen Sequence: |
GNCVKYPLRNLS |
| Post Translational Modifications | Phosphorylated. The phosphorylation regulates the activity. |
| Function | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. |
| Protein Name | Calcium-Binding Protein 1Cabp1CalbrainCaldendrin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembraneLipid-AnchorCytoplasmic SideGolgi ApparatusPostsynaptic DensityL-Cabp1 Is Associated Most Likely With The Cytoskeletal StructuresWhereas S-Cabp1 Is Localized At Or Near The Plasma MembraneIsoform L-Cabp1: CytoplasmIsoform S-Cabp1: CytoplasmCell CortexS-Cabp1 Is Localized At Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcium-Binding Protein 1 antibodyAnti-Cabp1 antibodyAnti-Calbrain antibodyAnti-Caldendrin antibodyAnti-CABP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
