Anti-CABP antibody [R27-2M-1] (STJA0035644)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human CABP
General Information
| Short Description | Rabbit monoclonal anti-CABP for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R27-2M-1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CABP1 |
| Gene ID | 9478 |
| Uniprot ID | CABP1_HUMAN |
| Immunogen | A synthesized peptide derived from human CABP |
Additional Info
| Tissue Specificity | Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum. |
| Post Translational Modifications | Phosphorylated. The phosphorylation regulates the activity. |
| Function | Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina. |
| Protein Name | Calcium-Binding Protein 1Cabp1CalbrainCaldendrin |
| Database Links | Reactome: R-HSA-9662360 |
| Cellular Localisation | CytoplasmCytoskeletonPerinuclear RegionCell MembraneLipid-AnchorCytoplasmic SideGolgi ApparatusPostsynaptic DensityL-Cabp1 Is Associated Most Likely With The Cytoskeletal StructuresWhereas S-Cabp1 Is Localized At Or Near The Plasma MembraneIsoform L-Cabp1: CytoplasmIsoform S-Cabp1: CytoplasmCell CortexS-Cabp1 Is Localized At Or Near The Plasma Membrane |
| Alternative Antibody Names | Anti-Calcium-Binding Protein 1 antibodyAnti-Cabp1 antibodyAnti-Calbrain antibodyAnti-Caldendrin antibodyAnti-CABP1 antibody |
Information sourced from Uniprot.org