• Human ovarian carcinoma stained with anti-CA125 antibody using peroxidase-conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

Anti-CA125/MUC16 antibody (Full length) [ZM53] (STJ180303)

SKU:
STJ180303

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CA125/MUC16 (Full length) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZM53
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: MUC16
Gene ID: 94025
Uniprot ID: MUC16_HUMAN
Immunogen Region: Full length
Specificity: Positive control: Ovarian carcinoma
Immunogen: Full length native CA125 protein purified from human ovarian carcinoma
Tissue Specificity Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.
Post Translational Modifications Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Function Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Protein Name Mucin-16
Muc-16
Ovarian Cancer-Related Tumor Marker Ca125
Ca-125
Ovarian Carcinoma Antigen Ca125
Database Links Reactome: R-HSA-5083625
Reactome: R-HSA-5083632
Reactome: R-HSA-5083636
Reactome: R-HSA-5621480
Reactome: R-HSA-913709
Reactome: R-HSA-977068
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Secreted
Extracellular Space
May Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain
Alternative Antibody Names Anti-Mucin-16 antibody
Anti-Muc-16 antibody
Anti-Ovarian Cancer-Related Tumor Marker Ca125 antibody
Anti-Ca-125 antibody
Anti-Ovarian Carcinoma Antigen Ca125 antibody
Anti-MUC16 antibody
Anti-CA125 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance