Anti-C6 antibody (586-934) (STJ112209)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C6 (586-934) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C6 |
| Gene ID | 729 |
| Uniprot ID | CO6_HUMAN |
| Immunogen Region | 586-934 |
| Immunogen Sequence | TRECNNPAPQRGGKRCEGEK RQEEDCTFSIMENNGQPCIN DDEEMKEVDLPEIEADSGCP QPVPPENGFIRNEKQLYLVG EDVEISCLTGFETVGYQYFR CLPDGTWRQGDVECQRTECI KPVVQEVLTITPFQRLYRIG ESIELTCPKGFVVAGPSRYT CQGNSWTPPISNSLTCEKDT LTKLKGHCQLGQKQSGSECI CMSPEEDCSHHSEDLCVFDT DSNDYFTSPACKFLAEKCL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 586-934 of human C6 (NP_000056.2). |
Additional Info
| Post Translational Modifications | All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. |
| Function | Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending. |
| Protein Name | Complement Component C6 |
| Database Links | Reactome: R-HSA-166665Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedTarget Cell MembraneMulti-Pass Membrane ProteinSecreted As Soluble ProteinInserts Into The Cell Membrane Of Target Cells |
| Alternative Antibody Names | Anti-Complement Component C6 antibodyAnti-C6 antibody |
Information sourced from Uniprot.org