Anti-C2CD5 antibody (732-1051) (STJ116569)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C2CD5 (732-1051) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C2CD5 |
| Gene ID | 9847 |
| Uniprot ID | C2CD5_HUMAN |
| Immunogen Region | 732-1051 |
| Immunogen Sequence | RLSSLNLTNQALNKNFNDLC ENLLKSLYFKLRSMIPCCLC HVNFTVSLPEDELIQVTVTA VAITFDKNQALQTTKTPVEK SLQRASTDNEELLQFPLELC SDSLPSHPFPPAKEHLESAS SNSGIPAAQRATSVDYSSFA DRCSSWIELIKLKAQTIRRG SIKTTMTVEKASPVGDGNFR NRSAPPCANSTVGVVKMTPL SFIPGAKITKYLGIINMFFI RETTSLREEGGVSGFLHAF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 732-1051 of human C2CD5 (NP_001273103.1). |
Additional Info
| Post Translational Modifications | Phosphorylated on Ser-197 by active myristoylated kinase AKT2.insulin-stimulated phosphorylation by AKT2 regulates SLC2A4/GLUT4 translocation into the plasma membrane. |
| Function | Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. |
| Protein Name | C2 Domain-Containing Protein 5C2 Domain-Containing Phosphoprotein Of 138 Kda |
| Database Links | Reactome: R-HSA-1445148 |
| Cellular Localisation | Cytoplasmic Vesicle MembraneCytoplasmCell CortexCell MembraneCell ProjectionRuffleDynamically Associated With Glut4-Containing Glucose Storage Vesicles (Gsv) And Plasma Membrane In Response To Insulin Stimulation |
| Alternative Antibody Names | Anti-C2 Domain-Containing Protein 5 antibodyAnti-C2 Domain-Containing Phosphoprotein Of 138 Kda antibodyAnti-C2CD5 antibodyAnti-CDP138 antibodyAnti-KIAA0528 antibody |
Information sourced from Uniprot.org