Anti-C2 antibody (STJ193122)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Complement C2 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C2 |
| Gene ID | 717 |
| Uniprot ID | CO2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CO2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems. Serine protease complement C2b: Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex. |
| Protein Name | Complement C2C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-174577Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceRecruited To The Surface Of Pathogens By Complement C3b And Complement C4b Opsonins |
| Alternative Antibody Names | Anti-Complement C2 antibodyAnti-C3/C5 Convertase Cleaved Into - Complement C2a - Serine Protease Complement C2b antibodyAnti-C2 antibody |
Information sourced from Uniprot.org