Anti-C1QA antibody (23-245) (STJ26180)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C1QA (23-245) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | C1QA |
| Gene ID | 712 |
| Uniprot ID | C1QA_HUMAN |
| Immunogen Region | 23-245 |
| Immunogen Sequence | EDLCRAPDGKKGEAGRPGRR GRPGLKGEQGEPGAPGIRTG IQGLKGDQGEPGPSGNPGKV GYPGPSGPLGARGIPGIKGT KGSPGNIKDQPRPAFSAIRR NPPMGGNVVIFDTVITNQEE PYQNHSGRFVCTVPGYYYFT FQVLSQWEICLSIVSSSRGQ VRRSLGFCDTTNKGLFQVVS GGMVLQLQQGDQVWVEKDPK KGHIYQGSEADSVFSGFLIF PSA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of human C1QA (NP_001334394.1). |
Additional Info
| Post Translational Modifications | O-linked glycans are assumed to be the Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains. |
| Function | Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system. |
| Protein Name | Complement C1q Subcomponent Subunit A |
| Database Links | Reactome: R-HSA-166663Reactome: R-HSA-173623Reactome: R-HSA-977606 |
| Cellular Localisation | SecretedCell SurfaceSpecifically Binds Igg Or Igm Immunoglobulins Complexed With AntigensForming Antigen-Antibody Complexes On The Surface Of Pathogens |
| Alternative Antibody Names | Anti-Complement C1q Subcomponent Subunit A antibodyAnti-C1QA antibody |
Information sourced from Uniprot.org