| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:500-1:1000IF/ICC:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | C1qa |
| Gene ID: | 12259 |
| Uniprot ID: | C1QA_MOUSE |
| Immunogen Region: | 23-245 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-245 of mouse C1qa (NP_031598.2). |
| Immunogen Sequence: | EDVCRAPNGKDGAPGNPGRP GRPGLKGERGEPGAAGIRTG IRGFKGDPGESGPPGKPGNV GLPGPSGPLGDSGPQGLKGV KGNPGNIRDQPRPAFSAIRQ NPMTLGNVVIFDKVLTNQES PYQNHTGRFICAVPGFYYFN FQVISKWDLCLFIKSSSGGQ PRDSLSFSNTNNKGLFQVLA GGTVLQLRRGDEVWIEKDPA KGRIYQGTEADSIFSGFLIF PSA |
| Post Translational Modifications | O-linked glycans are Glc-Gal disaccharides typically found as secondary modifications of hydroxylated lysines in collagen-like domains. Proline residues in the collagen-like domain motif, GXPG, are typically 4-hydroxylated. |
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. |
| Protein Name | Complement C1q Subcomponent Subunit A |
| Database Links | Reactome: R-MMU-166663Reactome: -MMU-173623Reactome: -MMU-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Complement C1q Subcomponent Subunit A antibodyAnti-C1qa antibody |
Information sourced from Uniprot.org