Anti-C19orf10 antibody (1-173) (STJ22849)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C19orf10 (1-173) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYDGF |
| Gene ID | 56005 |
| Uniprot ID | MYDGF_HUMAN |
| Immunogen Region | 1-173 |
| Immunogen Sequence | MAAPSGGWNGVGASLWAALL LGAVALRPAEAVSEPTTVAF DVRPGGVVHSFSHNVGPGDK YTCMFTYASQGGTNEQWQMS LGTSEDHQHFTCTIWRPQGK SYLYFTQFKAEVRGAEIEYA MAYSKAAFERESDVPLKTEE FEVTKTAVAHRPGAFKAELS KLVIVAKASRTEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human C19orf10 (NP_061980.1). |
Additional Info
| Tissue Specificity | Expressed in eosinophils (at protein level). Expressed in bone marrow cells. Expressed in synovial tissue. Found in synovial fluid of patients with arthropaties. |
| Function | Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway. Involved in endothelial cell proliferation and angiogenesis. |
| Protein Name | Myeloid-Derived Growth FactorMydgf |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | SecretedEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumGolgi ApparatusThe C-Terminal Rtel Motif May Provide Retention In The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Myeloid-Derived Growth Factor antibodyAnti-Mydgf antibodyAnti-MYDGF antibodyAnti-C19orf10 antibody |
Information sourced from Uniprot.org