• STJ71087 (2. 5µg/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Anti-C14orf68 antibody (Internal) (STJ71087)

SKU:
STJ71087-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-C14orf68 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-Recommended concentration, 2.5µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SLC25A47
Gene ID: 283600
Uniprot ID: S2547_HUMAN
Immunogen Region: Internal
Accession Number: NP_997000.2
Immunogen Sequence: RYGNPDAKPTKAD
Function Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated.
Protein Name Solute Carrier Family 25 Member 47
Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein
Mitochondrial Nad(+ Transporter Slc25a47
Cellular Localisation Mitochondrion Inner Membrane
Multi-Pass Membrane Protein
Mitochondrion Outer Membrane
Alternative Antibody Names Anti-Solute Carrier Family 25 Member 47 antibody
Anti-Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein antibody
Anti-Mitochondrial Nad(+ Transporter Slc25a47 antibody
Anti-SLC25A47 antibody
Anti-C14orf68 antibody
Anti-HDMCP antibody
Anti-HMFN1655 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance