| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-C14orf68 (242-254) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 2.5µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SLC25A47 |
| Gene ID: |
283600 |
| Uniprot ID: |
S2547_HUMAN |
| Immunogen Region: |
242-254 |
| Accession Number: |
NP_997000.2 |
| Immunogen Sequence: |
KSRLQADGQGQRR |
| Function | Mitochondrial NAD(+) transporter that acts as a 'metabolic gate' in hepatic lipogenesis. Provides NAD(+) substrate to mitochondrial SIRT3 deacetylase and enables its NAD(+)-dependent activities in mitochondrial energy metabolism. This triggers downstream activation of PRKAA1/AMPK-alpha signaling cascade that negatively regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance. May transport other mitochondrial metabolites having an aromatic nucleotide and phosphate groups, such as acetyl-CoA. Does not transport amino acids. The transport mechanism remains to be elucidated. |
| Protein Name | Solute Carrier Family 25 Member 47Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier ProteinMitochondrial Nad(+ Transporter Slc25a47 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Solute Carrier Family 25 Member 47 antibodyAnti-Hepatocellular Carcinoma Down-Regulated Mitochondrial Carrier Protein antibodyAnti-Mitochondrial Nad(+ Transporter Slc25a47 antibodyAnti-SLC25A47 antibodyAnti-C14orf68 antibodyAnti-HDMCP antibodyAnti-HMFN1655 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
