Anti-C11orf30 antibody (1153-1322) (STJ27891)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C11orf30 (1153-1322) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | EMSY |
| Gene ID | 56946 |
| Uniprot ID | EMSY_HUMAN |
| Immunogen Region | 1153-1322 |
| Immunogen Sequence | SLMEAQIDTNVEHMIVDPPK KALATSMLTGEAGSLPSTHM VVAGMANSTPQQQKCRESCS SPSTVGSSLTTRKIDPPAVP ATGQFMRIQNVGQKKAEESP AEIIIQAIPQYAIPCHSSSN VVVEPSGLLELNNFTSQQLD DEETAMEQDIDSSTEDGTEP SPSQSSAERS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1322 of human C11orf30 (NP_064578.2). |
Additional Info
| Post Translational Modifications | O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. |
| Function | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. |
| Protein Name | Brca2-Interacting Transcriptional Repressor Emsy |
| Database Links | |
| Cellular Localisation | NucleusLocalizes To Dna Damage Markers In Irradiated CellsSuggesting That It Participates In Dna Repair Process |
| Alternative Antibody Names | Anti-Brca2-Interacting Transcriptional Repressor Emsy antibodyAnti-EMSY antibodyAnti-C11orf30 antibodyAnti-GL002 antibody |
Information sourced from Uniprot.org