Anti-BVES antibody (STJ190612)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Blood vessel epicardial substance for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | POPDC1 |
| Gene ID | 11149 |
| Uniprot ID | POPD1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | POPD1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density. Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury. |
| Protein Name | Popeye Domain-Containing Protein 1Popeye Protein 1 |
| Database Links | |
| Cellular Localisation | Lateral Cell MembraneCell JunctionTight JunctionMembraneMulti-Pass Membrane ProteinCell MembraneSarcolemmaCaveolaColocalizes With Vamp3 At The Cell-Cell Contact In Cardiac And Skeletal MuscleIts Movement From The Cytoplasm To Membrane Is An Early Event Occurring Concurrently With Cell-Cell ContactColocalizes In Epithelial Cells With Ocln And Tjp1 In An Apical-Lateral Position Within The Z AxisDetected At Cell-Cell Contact But Never Observed At The Free Surface Of Epithelial Cells |
| Alternative Antibody Names | Anti-Popeye Domain-Containing Protein 1 antibodyAnti-Popeye Protein 1 antibodyAnti-POPDC1 antibodyAnti-BVES antibodyAnti-POP1 antibody |
Information sourced from Uniprot.org