| Short Description : | Rabbit polyclonal BTF3 (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BTF3 |
| Gene ID: | 689 |
| Uniprot ID: | BTF3_HUMAN |
| Immunogen Region: | 50-150 |
| Immunogen Sequence: | KLGVNNISGIEEVNMFTNQG TVIHFNNPKVQASLAANTFT ITGHAETKQLTEMLPSILNQ LGADSLTSLRRLAEALPKQS VDGKAPLATGEDDDDEVPDL V |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human BTF3 (NP_001198.2). |
| Function | When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. |
| Protein Name | Transcription Factor Btf3Nascent Polypeptide-Associated Complex Subunit BetaNac-BetaRna Polymerase B Transcription Factor 3 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusThe Heterodimer With Naca Is Cytoplasmic |
| Alternative Antibody Names | Anti-Transcription Factor Btf3 antibodyAnti-Nascent Polypeptide-Associated Complex Subunit Beta antibodyAnti-Nac-Beta antibodyAnti-Rna Polymerase B Transcription Factor 3 antibodyAnti-BTF3 antibodyAnti-NACB antibodyAnti-OK antibodyAnti-SW-cl.8 antibody |
Information sourced from Uniprot.org
