Anti-BRMS1 antibody [R95-6M-2] (STJA0035519)

Name: Anti-BRMS1 antibody [R95-6M-2] (STJA0035519)
SKU: STJA0035519
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenA synthesized peptide derived from human BRMS1

STJA0035519

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Short Description	Rabbit monoclonal anti-BRMS1 for use in WB, IHC-P, ICC, IF and IP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ICC/IF/IP
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	R95-6M-2
Isotype	IgG
Conjugation	Unconjugated
Purification	Affinity Chromatography
Dilution Range	WB 1:500-1:1000 IHC 1:100-1:200 IF 1:50-1:200 IP 1:50
Formulation	Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Instruction	Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.

Gene Symbol	BRMS1
Gene ID	25855
Uniprot ID	BRMS1_HUMAN
Immunogen	A synthesized peptide derived from human BRMS1

Tissue Specificity	Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Post Translational Modifications	Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Function	Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Protein Name	Breast Cancer Metastasis-Suppressor 1
Database Links	Reactome: R-HSA-3214815 Reactome: R-HSA-9679191
Cellular Localisation	Nucleus Cytoplasm Predominantly Nuclear
Alternative Antibody Names	Anti-Breast Cancer Metastasis-Suppressor 1 antibody Anti-BRMS1 antibody

Information sourced from Uniprot.org