Anti-BRMS1 antibody (21-70 aa) (STJ91892)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human BRMS1 at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Breast cancer metastasis-suppressor 1 (21-70 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BRMS1 |
| Gene ID | 25855 |
| Uniprot ID | BRMS1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human BRMS1 at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | BRMS-1 Polyclonal Antibody detects endogenous levels of BRMS-1 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation. |
| Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. |
| Protein Name | Breast Cancer Metastasis-Suppressor 1 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-9679191 |
| Cellular Localisation | NucleusCytoplasmPredominantly Nuclear |
| Alternative Antibody Names | Anti-Breast Cancer Metastasis-Suppressor 1 antibodyAnti-BRMS1 antibody |
Information sourced from Uniprot.org