• Formalin-fixed and paraffin-embedded human ovarian small cell carcinoma stained with anti-ERG1 antibody using peroxidase-conjugate and DAB chromogen. Note the absence of nuclear staining of tumor cells were retained nuclear staining of background inflammatory cells and endothelial cells

Anti-BRG1/SMARC4 antibody [ZR390] (STJ180549)

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STJ180549

£188.50 - £795.50
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-BRG1/SMARC4 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZR390
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: TBRG1
Gene ID: 84897
Uniprot ID: TBRG1_HUMAN
Specificity: Positive Control: Normal human tissue
Immunogen: Recombinant fragment (around aa 200-400) of human SMARCA4 protein (exact sequence is proprietary)
Tissue Specificity Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
Post Translational Modifications Ubiquitinated.mediated by MDM2 and leading to its subsequent proteasomal degradation.
Function Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability.
Protein Name Transforming Growth Factor Beta Regulator 1
Nuclear Interactor Of Arf And Mdm2
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transforming Growth Factor Beta Regulator 1 antibody
Anti-Nuclear Interactor Of Arf And Mdm2 antibody
Anti-TBRG1 antibody
Anti-NIAM antibody

Information sourced from Uniprot.org

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