Anti-BRD7 antibody (1-95) (STJ11105077)

Name: Anti-BRD7 antibody (1-95) (STJ11105077)
SKU: STJ11105077
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11105077

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Short Description	Rabbit polyclonal Bromodomain-Containing Protein 7 (1-95) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	BRD7
Gene ID	29117
Uniprot ID	BRD7_HUMAN
Immunogen Region	1-95
Immunogen Sequence	MGKKHKKHKSDKHLYEEYVE KPLKLVLKVGGNEVTELSTG SSGHDSSLFEDKNDHDKHKD RKRKKRKKGEKQIPGEEKGR KRRRVKEDKKKRDRD
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-95 of human BRD7. (NP_037395.2).

Function	Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Protein Name	Bromodomain-Containing Protein 7 75 Kda Bromodomain Protein Protein Celtix-1
Database Links	Reactome: R-HSA-6804758
Cellular Localisation	Nucleus Chromosome Isoform 2: Nucleus
Alternative Antibody Names	Anti-Bromodomain-Containing Protein 7 antibody Anti-75 Kda Bromodomain Protein antibody Anti-Protein Celtix-1 antibody Anti-BRD7 antibody Anti-BP75 antibody Anti-CELTIX1 antibody

Information sourced from Uniprot.org