| Function | Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. |
| Protein Name | Brca1-Associated ProteinBrap2Impedes Mitogenic Signal PropagationImpRing Finger Protein 52Ring-Type E3 Ubiquitin Transferase Brap2Renal Carcinoma Antigen Ny-Ren-63 |
| Database Links | Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6802946Reactome: R-HSA-6802955Reactome: R-HSA-9649948 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Brca1-Associated Protein antibodyAnti-Brap2 antibodyAnti-Impedes Mitogenic Signal Propagation antibodyAnti-Imp antibodyAnti-Ring Finger Protein 52 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Brap2 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-63 antibodyAnti-BRAP antibodyAnti-RNF52 antibody |
Information sourced from Uniprot.org
