Anti-BPIFA1/PLUNC antibody (Internal) (STJ72784)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-BPIFA1/PLUNC (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 26kDa band observed in secretions of Human primary airway cells in culture-and in Human Bronchoalveolar Lavage fluid (calculated MW of 26.7kDa according to NP_057667.1). Recomm |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | BPIFA1 |
| Gene ID | 51297 |
| Uniprot ID | BPIA1_HUMAN |
| Accession Number | NP_057667.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | RDKQERIHLVLGDC |
| Specificity | Reported variants represent identical protein: NP_057667.1, NP_001230122.1, NP_570913.1 |
Additional Info
| Post Translational Modifications | May be N-glycosylated. |
| Function | Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. |
| Protein Name | Bpi Fold-Containing Family A Member 1Lung-Specific Protein XNasopharyngeal Carcinoma-Related ProteinPalate Lung And Nasal Epithelium Clone ProteinSecretory Protein In Upper Respiratory TractsShort Plunc1Splunc1Tracheal Epithelium-Enriched ProteinVon Ebner Protein Hl |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedApical Side Of Airway Epithelial CellsDetected In Airway Surface LiquidNasal Mucus And Sputum |
| Alternative Antibody Names | Anti-Bpi Fold-Containing Family A Member 1 antibodyAnti-Lung-Specific Protein X antibodyAnti-Nasopharyngeal Carcinoma-Related Protein antibodyAnti-Palate Lung And Nasal Epithelium Clone Protein antibodyAnti-Secretory Protein In Upper Respiratory Tracts antibodyAnti-Short Plunc1 antibodyAnti-Splunc1 antibodyAnti-Tracheal Epithelium-Enriched Protein antibodyAnti-Von Ebner Protein Hl antibodyAnti-BPIFA1 antibodyAnti-LUNX antibodyAnti-NASG antibodyAnti-PLUNC antibodyAnti-SPLUNC1 antibodyAnti-SPURT antibodyAnti-UNQ787 antibodyAnti-PRO1606 antibody |
Information sourced from Uniprot.org