Anti-BOK antibody (Internal) (STJ72368)

SKU:
STJ72368-100

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Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-BOK (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:8000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: BOK
Gene ID: 666
Uniprot ID: BOK_HUMAN
Immunogen Region: Internal
Accession Number: NP_115904.1
Immunogen Sequence: HISLQSEPVVTD
Post Translational Modifications Ubiquitinated by AMFR/gp78 E3 ubiquitin ligase complex.mediates degradation by ubiquitin-proteasome pathway in a VCP/p97-dependent manner.prevents from pro-apoptotic activity.promotes degradation of newly synthesized proteins that are not ITPR1 associated.
Function Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner. In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response. Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release. In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner. Plays a role in granulosa cell apoptosis by CASP3 activation. Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation. In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression. May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1. Isoform 2: Pro-apoptotic molecule exerting its function through the mitochondrial pathway.
Protein Name Bcl-2-Related Ovarian Killer Protein
Hbok
Bcl-2-Like Protein 9
Bcl2-L-9
Cellular Localisation Isoform 1: Mitochondrion Membrane
Single-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Mitochondrion Inner Membrane
Cytoplasm
Nucleus
Mitochondrion
Endoplasmic Reticulum
Mitochondrion Outer Membrane
Early Endosome Membrane
Recycling Endosome Membrane
Nucleus Outer Membrane
Golgi Apparatus
Cis-Golgi Network Membrane
Trans-Golgi Network Membrane
Membrane
Nuclear And Cytoplasmic Compartments In The Early Stages Of Apoptosis And During Apoptosis It Associates With Mitochondria
In Healthy Cells
Associates Loosely With The Membrane In A Hit-And-Run Mode
The Insertion And Accumulation On Membranes Is Enhanced Through The Activity Of Death Signals
Resulting In The Integration Of The Membrane-Bound Protein Into The Membrane
The Transmembrane Domain Controls Subcellular Localization
Constitutes A Tail-Anchor
Localizes In Early And Late Endosome Upon Blocking Of Apoptosis
Must Localize To The Mitochondria To Induce Mitochondrial Outer Membrane Permeabilization And Apoptosis
Isoform 2: Membrane
Alternative Antibody Names Anti-Bcl-2-Related Ovarian Killer Protein antibody
Anti-Hbok antibody
Anti-Bcl-2-Like Protein 9 antibody
Anti-Bcl2-L-9 antibody
Anti-BOK antibody
Anti-BCL2L9 antibody

Information sourced from Uniprot.org

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