Anti-BNIP3L antibody [R01-0F5] (STJA0034087)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human BNIP3L
General Information
| Short Description | Rabbit monoclonal anti-BNIP3L for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-0F5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | BNIP3L |
| Gene ID | 665 |
| Uniprot ID | BNI3L_HUMAN |
| Immunogen | A synthetic peptide of human BNIP3L |
Additional Info
| Post Translational Modifications | Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin. |
| Function | Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-LikeAdenovirus E1b19k-Binding Protein B5Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3aNip3-Like Protein XNip3l |
| Database Links | Reactome: R-HSA-6803204 |
| Cellular Localisation | Nucleus EnvelopeEndoplasmic ReticulumMitochondrion Outer MembraneMembraneSingle-Pass Membrane ProteinColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3-Like antibodyAnti-Adenovirus E1b19k-Binding Protein B5 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3a antibodyAnti-Nip3-Like Protein X antibodyAnti-Nip3l antibodyAnti-BNIP3L antibodyAnti-BNIP3A antibodyAnti-BNIP3H antibodyAnti-NIX antibody |
Information sourced from Uniprot.org