Anti-BNIP3 antibody (40-120) [S4836RM] (STJ11104836)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 (40-120) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4836RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BNIP3 |
| Gene ID | 664 |
| Uniprot ID | BNIP3_HUMAN |
| Immunogen Region | 40-120 |
| Immunogen Sequence | AFPPPAAEAHPAARRGLRSP QLPSGAMSQNGAPGMQEESL QGSWVELHFSNNGNGGSVPA SVSIYNGDMEKILLDAQHES G |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-120 of human BNIP3 (NP_004043.3). |
Additional Info
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. |
| Protein Name | Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 |
| Database Links | |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneSingle-Pass Membrane ProteinCoexpression With The Eib 19-Kda Protein Results In A Shift In Nip3 Localization Pattern To The Nuclear EnvelopeColocalizes With Acaa2 In The MitochondriaColocalizes With Spata18 At The Mitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 3 antibodyAnti-BNIP3 antibodyAnti-NIP3 antibody |
Information sourced from Uniprot.org