Anti-BNIP1 antibody (STJ191625)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Vesicle transport protein SEC20 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BNIP1 |
| Gene ID | 662 |
| Uniprot ID | SEC20_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SEC20 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. |
| Function | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). |
| Protein Name | Vesicle Transport Protein Sec20Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1Transformation-Related Gene 8 ProteinTrg-8 |
| Database Links | Reactome: R-HSA-6811434 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinMitochondrion MembraneLocalization To The Mitochondrion Is Regulated By Rnf186 |
| Alternative Antibody Names | Anti-Vesicle Transport Protein Sec20 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 antibodyAnti-Transformation-Related Gene 8 Protein antibodyAnti-Trg-8 antibodyAnti-BNIP1 antibodyAnti-NIP1 antibodyAnti-SEC20L antibodyAnti-TRG8 antibody |
Information sourced from Uniprot.org