Host: |
Goat |
Applications: |
Pep-ELISA/WB |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Goat polyclonal antibody anti-BNIP1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: |
0.5 mg/mL |
Dilution Range: |
WB-0.5-1.5µg/mlELISA-antibody detection limit dilution 1:8000. |
Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: |
BNIP1 |
Gene ID: |
662 |
Uniprot ID: |
SEC20_HUMAN |
Immunogen Region: |
Internal |
Accession Number: |
NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1 |
Specificity: |
All reported variants represent isoform 1 (NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1) |
Immunogen Sequence: |
DLLRQRKTTKESLAQ |
Post Translational Modifications | Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. |
Function | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). |
Protein Name | Vesicle Transport Protein Sec20Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1Transformation-Related Gene 8 ProteinTrg-8 |
Database Links | Reactome: R-HSA-6811434 |
Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinMitochondrion MembraneLocalization To The Mitochondrion Is Regulated By Rnf186 |
Alternative Antibody Names | Anti-Vesicle Transport Protein Sec20 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 antibodyAnti-Transformation-Related Gene 8 Protein antibodyAnti-Trg-8 antibodyAnti-BNIP1 antibodyAnti-NIP1 antibodyAnti-SEC20L antibodyAnti-TRG8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance