| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-BNIP1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.5-1.5µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
BNIP1 |
| Gene ID: |
662 |
| Uniprot ID: |
SEC20_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1 |
| Specificity: |
All reported variants represent isoform 1 (NP_001196.1; NP_053581.1; NP_053582.1; NP_053583.1) |
| Immunogen Sequence: |
DLLRQRKTTKESLAQ |
| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. |
| Function | As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy (Probable). |
| Protein Name | Vesicle Transport Protein Sec20Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1Transformation-Related Gene 8 ProteinTrg-8 |
| Database Links | Reactome: R-HSA-6811434 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinMitochondrion MembraneLocalization To The Mitochondrion Is Regulated By Rnf186 |
| Alternative Antibody Names | Anti-Vesicle Transport Protein Sec20 antibodyAnti-Bcl2/Adenovirus E1b 19 Kda Protein-Interacting Protein 1 antibodyAnti-Transformation-Related Gene 8 Protein antibodyAnti-Trg-8 antibodyAnti-BNIP1 antibodyAnti-NIP1 antibodyAnti-SEC20L antibodyAnti-TRG8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
