• Western blot analysis of lysates from A549 cells, using ETK Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of A549 cells, using ETK Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human thyroid gland tissue, using ETK Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Bmx Polyclonal Antibody diluted at 1:1000

Anti-BMX antibody (532-581 aa) (STJ91873)

SKU:
STJ91873

Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cytoplasmic tyrosine-protein kinase BMX (532-581 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BMX
Gene ID: 660
Uniprot ID: BMX_HUMAN
Immunogen Region: 532-581 aa
Specificity: Bmx Polyclonal Antibody detects endogenous levels of Bmx protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human C-ternal ETK at the amino acid range 532-581
Post Translational Modifications Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX.
Function Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells.as well as in signal transduction in endocardial and arterial endothelial cells.
Protein Name Cytoplasmic Tyrosine-Protein Kinase Bmx
Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein
Epithelial And Endothelial Tyrosine Kinase
Etk
Ntk38
Database Links Reactome: R-HSA-111465
Reactome: R-HSA-1660499
Cellular Localisation Cytoplasm
Localizes To The Edges Of Spreading Cells When Complexed With Bcar1
Alternative Antibody Names Anti-Cytoplasmic Tyrosine-Protein Kinase Bmx antibody
Anti-Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein antibody
Anti-Epithelial And Endothelial Tyrosine Kinase antibody
Anti-Etk antibody
Anti-Ntk38 antibody
Anti-BMX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance