Anti-BMX antibody (1-120) (STJ117827)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal BMX (1-120) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | BMX |
| Gene ID | 660 |
| Uniprot ID | BMX_HUMAN |
| Immunogen Region | 1-120 |
| Immunogen Sequence | MDTKSILEELLLKRSQQKKK MSPNNYKERLFVLTKTNLSY YEYDKMKRGSRKGSIEIKKI RCVEKVNLEEQTPVERQYPF QIVYKDGLLYVYASNEESRS QWLKALQKEIRGNPHLLVKY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human BMX (NP_001712.1). |
Additional Info
| Tissue Specificity | Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. |
| Post Translational Modifications | Phosphorylated in response to protein I/II and to LPS. Phosphorylation at Tyr-566 by SRC and by autocatalysis leads to activation and is required for STAT3 phosphorylation by BMX. |
| Function | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Also plays a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells.as well as in signal transduction in endocardial and arterial endothelial cells. |
| Protein Name | Cytoplasmic Tyrosine-Protein Kinase BmxBone Marrow Tyrosine Kinase Gene In Chromosome X ProteinEpithelial And Endothelial Tyrosine KinaseEtkNtk38 |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmLocalizes To The Edges Of Spreading Cells When Complexed With Bcar1 |
| Alternative Antibody Names | Anti-Cytoplasmic Tyrosine-Protein Kinase Bmx antibodyAnti-Bone Marrow Tyrosine Kinase Gene In Chromosome X Protein antibodyAnti-Epithelial And Endothelial Tyrosine Kinase antibodyAnti-Etk antibodyAnti-Ntk38 antibodyAnti-BMX antibody |
Information sourced from Uniprot.org